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In the STEP-1 obesity trial, semaglutide 2.4 mg weekly produced roughly 14.9% mean body-weight loss over 68 weeks ( Wilding et al., NEJM 2021 )
That is, tolerability often beats speed when the goal is durable change
Barrea L, Pugliese G, Muscogiuri G, Laudisio D, Colao A, Savastano S
Week 12: starting Ozempic Ozempic comes in a pre-filled pen that you inject under the skin (in the thigh, abdomen, or upper arm) once weekly, on the same day and time each week
Some cases occur sporadically with an unknown etiology (27)
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